The safe & effective solution for cleaning red, itchy, crusty, inflamed eyes

Primocyn Eye Cleanser is the safe & effective solution to good eyelid & eyelash hygiene.

  • hypochlorous acid (HOCl)
  • Steroid-Free
  • Antibiotic-Free
  • Non-Irritating
  • Non-Cytotoxic
  • Non-Sensitizing
  • Requires No Special Handling

For the safe and effective removal of encrustation and debris.
Primocyn Eye Cleanser contains hypochlorous acid (HOCl) which has been proven to be safe in over five million users to date. HOCl at the concentration levels found in Primocyn Eye Cleanser can be used safely around eyes, ears, nose, and mouth.

What is hypochlorous acid (HOCl)?

HOCl is a compound that is produced naturally by the immune system, particularly neutrophils, to eradicate microorganisms.1

Benefits of HOCl
Stabilized hypochlorous acid (HOCl) helps reduce itch, inflammation and pain. It is also a powerful antimicrobial that kills skin pathogens associated with blepharitis, MGD, demodex and dry eye.

Who will HOCl help and what are the benefits?

HOCl has several specific properties that are beneficial for various skin conditions including those around eyelids and eyelashes. These include:

  • Potent antimicrobial
  • Reduction of pain and itch
  • Reduction of inflammation
  • Breaks down biofilm formed by S. aureus
Blepharitis Blepharitis
MGD MGD
Demodex Demodex
Dry Eye Dry Eye

Not all HOCl solutions are created equal

The positive effects of HOCl on the human body, both inside and out, have been studied and Recognized by medical scientists worldwide for over 100 years.

Today, Hypochlorous acid is bottled in a stabilized form so that you have a weapon to use against The countless environmental aggressors that threaten the health of your skin.

Don’t be fooled by others who claim to have superior HOCl solutions. Primocyn’s original HOCl formulas have been continuously improved over time and have set the standard of quality, stability and efficacy.

Potent Antimicrobial

Time Kill Study: In vitro HOCl eradication of pathogens

  • Greater than 99% reduction in killing 23 different microorganisms, including S. aureus and S. aureus-MRSA
  • Time to kill 30 seconds
Name of Organism Log Reduction Log Reduction Percent Reduction
Acinetobacter baumannii 7.0488 30 seconds 99.9999%
Bacteroides fragilis 3.3565 30 seconds 99.9560%
Candida albicans 6.4699 30 seconds 99.9999%
Corynebacterium diphtherieae 5.2778 30 seconds 99.9995%
Clostridium difficile (spores) 4.6085 30 seconds 99.9975%
Enterobacter aerogenes 6.7200 30 seconds 99.9999%
Enterococcus faecalis-VRE MDR 5.6085 30 seconds 99.9998%
Escherichia coli 6.5272 30 seconds 99.9999%
Haemophilus influenzae 5.4107 30 seconds 99.9996%
Klebsiella oxytoca 6.7810 30 seconds 99.9999%
Klebsiella pneumoniae ozaenae
6.8086 30 seconds 99.9999%
Malassezia furfur 5.3953 30 seconds 99.9996%
Micrococcus yunnanensis 5.6137 30 seconds 99.9998%
Propionibacterium acnes 5.2967 30 seconds 99.9995%
Proteus mirabilis 6.7477 30 seconds 99.9999%
Pseudomonas aeruginosa 6.5867 30 seconds 99.9999%
Serratia marcescens 6.5811 30 seconds 99.9999%
Staphylococcus aureus-MRSA 6.7032 30 seconds 99.9999%
Staphylococcus aureus 6.5008 30 seconds 99.9999%
Staphylococcus pyogenes
6.4214 30 seconds 99.9999%
Trichophyton mentagrophytes
4.6752 30 seconds 99.9979%
Trichophyton rubrum
2.5234 30 seconds 99.7004%
Vibrio vulnificus
5.1888 30 seconds 99.9994%

Reduction in Pain and Itch

Case Study #1

Open-Label Study

Study Design
  • Open-label, single-arm study over 7 days
Results
  • HOCl rapidly reduces pruritus in mild-to-moderate atopic dermatitis (AD)
    • 50% of patients experienced a reduction by Day 1
    • 85% of patients experienced a reduction by Day 3
Percent of patients with improvement in pruritus
Percent of patients with improvement in pruritus

Case Study #2

Randomized, Blinded, Controlled Study

Study Design
  • 72-hour study
  • Treated group (n=19): HOCl BID
  • Untreated group (n=10): No treatment
Results
  • Mean pruritus VAS scores between treated and untreated group were significantly different between baseline and 72 hours post application
Percent mean change in pruritus VAS
Percent mean change in pruritus VAS

Anti-Inflammatory Activity

HOCl for Inhibition of Mast Cell Degranulation

  • Prevents allergen- and calcium-induced mast cell degranulation for up to 8 hours after a single exposure in-vitro
  • Reduces wound inflammation that inhibits healing
  • Stabilizes the mast cell membrane to inhibit the cell machinery for granule secretion, while not altering the signal transduction pathways or calcium mobilization
  • Inhibits degranulation stimulated by antigen or calcium ionophore
HOCI inhibition of mast cell degranulation stimulated by antigen or calcium lonophore
HOCI inhibition of mast cell degranulation stimulated by antigen or calcium lonophore

*A23187 + PMA is a calcium ionophore; †b-hexosaminidase is a marker of IgE-antigen-induced mast cell degranulation.

Breaks Down Bacterial Biofilm

Biofilm formation is recognized as a serious problem in chronic wound infections. Biofilm characteristics include

  • Complex structure of microorganisms that generate a protective shell, allowing bacteria to collect and proliferate
  • Most microorganisms that form biofilms found growing in microbial infection
  • Adheres to chronic wounds, makes phagocytosis difficult, and increases resistance to antibiotics
  • Inhibits degranulation stimulated by antigen or calcium ionophore

HOCl has antibiofilm activity and actively breaks down biofilm and kills microorganisms within the biofilm.

In vitro biofilm eradication of slime-producing S. aureus with serial dilutions of HOCI
In vitro biofilm eradication of slime-producing S. aureus with serial dilutions of HOCI

Corresponding microbicidal activity: 1/64 and lower dilutions of HOCl demonstrated zero colony-forming units of S. aureus

Increases Oxygenation

Oxygen
  • Provides higher levels of oxygen at a wound site after application
  • Elevated blood and oxygen flow increases wound-healing nutrients

Assists Wound Healing

Wound healing involves a complex sequence of events. Fibroblasts are the primary synthetic cells in the repair process of most structural proteins used during tissue reconstruction.

At lower concentrations, the percentage of fibroblast migration exceeded that of the control at 24 hours.

Effect of HOCI on skin fibroblast cell migration in a wound healing assay
Effect of HOCI on skin fibroblast cell migration in a wound healing assay

Although fibroblasts have a critical role in wound healing, their proliferation highly relates to keratinocyte proliferation and mediators secreted from keratinocytes.

Similar results were obtained for keratinocyte migration: At lower HOCl concentrations, the percentage of keratinocyte migration exceeded that of the control at 24 hours

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